Saw your lovely podcast with Benjamin Boyce. And I just wanted to message you a couple snippets of information that might be helpful as you construct your book! (No idea if you will see this since I am just an Anonymous account on Twitter, which doesn’t tweet or have anyone follow me.) But as a current medical student interested in this stuff, I just wanted to shoot you a comment with some more bits of medical context that you might consider when constructing your book, or maybe just find interesting, because you clearly love learning about endocrinology, and the current dynamics, governing transgender medicine.
1 small correction: I think you called Lupron a GnRH antagonist. (blocker) As in it simply blocks the release of GnRH. But interestingly Lupron is actually an agonist - as in it stimulates the GnRH receptors. And then this overstimulation basically shuts the production of GnRH down. (bunch of hypothalamic hormones are regulated by and also secrete in a pulsatile pattern. Frequency of pulse determines release or not.) ….. so lupron = GnRH AGONIST that weirdly SUPPRESSES GnRH release.
## (GnRH ANTAGonists are actually some thing that is a bit NEWER than lupron - **Linzagolix, ganirelix, cetrorelix-** and usually used for breast / prostate cancer. May eventually become the standard of care for those malignancies. But Tbd.)
Also yes messing with GnRH treats both precocious puberty and breast cancer, but you should also know it treats prostate cancer also which is pretty cool. Because prostate cancer basically grows off more testosterone. And so if you shut down that FSH and LH you shut down testosterone production too. → stop stimulating prostate tissue proliferation.
(So basically I’m just trying to tell you that Lupron is a GNRH AGONIST not ANTAGonist… which is basically the same thing, but different LOL. - and still good to get those little details right if you want physicians to read your work and take it seriously from a technical perspective!)
"So What If Gender is a Social Construct?":
https://open.substack.com/pub/johncarpenter/p/the-transgender-bait-and-switch-b0b?r=yky21&utm_campaign=post&utm_medium=web
Saw your lovely podcast with Benjamin Boyce. And I just wanted to message you a couple snippets of information that might be helpful as you construct your book! (No idea if you will see this since I am just an Anonymous account on Twitter, which doesn’t tweet or have anyone follow me.) But as a current medical student interested in this stuff, I just wanted to shoot you a comment with some more bits of medical context that you might consider when constructing your book, or maybe just find interesting, because you clearly love learning about endocrinology, and the current dynamics, governing transgender medicine.
1 small correction: I think you called Lupron a GnRH antagonist. (blocker) As in it simply blocks the release of GnRH. But interestingly Lupron is actually an agonist - as in it stimulates the GnRH receptors. And then this overstimulation basically shuts the production of GnRH down. (bunch of hypothalamic hormones are regulated by and also secrete in a pulsatile pattern. Frequency of pulse determines release or not.) ….. so lupron = GnRH AGONIST that weirdly SUPPRESSES GnRH release.
## (GnRH ANTAGonists are actually some thing that is a bit NEWER than lupron - **Linzagolix, ganirelix, cetrorelix-** and usually used for breast / prostate cancer. May eventually become the standard of care for those malignancies. But Tbd.)
Also yes messing with GnRH treats both precocious puberty and breast cancer, but you should also know it treats prostate cancer also which is pretty cool. Because prostate cancer basically grows off more testosterone. And so if you shut down that FSH and LH you shut down testosterone production too. → stop stimulating prostate tissue proliferation.
(So basically I’m just trying to tell you that Lupron is a GNRH AGONIST not ANTAGonist… which is basically the same thing, but different LOL. - and still good to get those little details right if you want physicians to read your work and take it seriously from a technical perspective!)